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ATR inhibition prematurely activates FOXM1, deregulating the S/G 2 transition and leading to early mitosis, underreplicated DNA, and DNA damage. kenapa dota 2 tidak bisa play Thus, ATR couples DNA replication with mitosis and preserves genome integrity by enforcing an S/G 2 checkpoint. little forest viu ep 2 To avoid loss of genetic information, cells must replicate their DNA before mitosis ( 1 )